病理学——泌尿系统PPT课件.ppt

泌尿系统疾病 The Kidney and its collecting system;肾脏功能;Normal adult kidney;Normal adult kidney;;;4 basic morphologic components;流行病学; 血 透;腹 透;肾小球疾病 Glomerular diseases;;; Visceral epithelial cells (podocytes) scanning electron micrograph ;水和离子自由通过，蛋白不能通过 size-dependent (3.5 nm) charge-dependent (the polyanions）;肾小球损伤的机制;;肾穿刺 Renal puncture;Electron microscopy ;电子致密物沉积 ;Granular, characteristic of circulating and in situ immune complex deposition ;Linear, characteristic of classic anti-GBM antibody GN ;Normal glomerulus stained with HE;Normal glomerulus stained with PAS;how does glomerular damage ensue?;1;急性弥漫增生性肾小球肾炎毛细血管内增生性肾小球肾炎(链球菌)感染后性肾小球肾炎;Acute post-streptococcal GN;Acute diffuse proliferative GN;;Normal;Acute diffuse proliferative GN;EM;Immunofluorescence (Ig and complement);内皮细胞和系膜细胞弥漫性肿胀，增生;;预 后;;Goodpastures GN, anti IgG;;;Crescentic GN (PAS stain);;;预 后;膜性肾小球肾炎/膜性肾病 ;;Normal ; ;?; ;;Immunofluorescence (Ig and complement);;;;GBM damaged;预 后 ;轻微肾小球病变/脂性肾病 ;;;;;临床表现及预后;膜性增生性肾小球肾炎 ;发病机制 ;;; (PAS stain); (Silver stain); (Silver stain);;NPGN, Type II;临床表现及预后;IgA肾病 Berger disease ;发病机制;;;临床表现及预后;慢性肾小球肾炎 ;;;;;;Hyaline obliteration of glomeruli Tubules are lost, vessel walls are thickened;(Masson trichrome stain);临床病理联系;Clinical manifestations of renal disease ;急性肾盂肾炎 Acute pyelonephritis;;Predisposing conditions;膀胱输尿管返流;急性肾盂肾炎;急性肾盂肾炎;急性肾盂肾炎;急性肾盂肾炎;;;;肾乳头坏死;临床表现;慢性肾盂肾炎 Chronic pyelonephritis;;;;甲状腺样变;;临床表现;Thank You !;*