蛋白激酶与磷酸酶ppt课件.pptx

蛋白激酶与磷酸酶;蛋白质翻译后修饰;磷酸化修饰的氨基酸;蛋白质的磷酸化修饰;2021/4/24;蛋白激酶将ATP末端的磷酸基团转移到蛋白质侧链的羟基上； 磷酸酶催化蛋白质侧链上磷酸基团的水解。; ~30%的蛋白质可以发生磷酸化修饰;蛋白激酶的结构;蛋白激酶的分类;受体酪氨酸激酶（RTK）;Six subfamilies of receptor tyrosine kinases involved in cell growth and differentiation. Only one or two members of each subfamily are indicated. Note that the tyrosine kinase domain is interrupted by a kinase insert region in some of the subfamilies. The functional significance of the cysteine-rich and immunoglobulin-like domains is unknown. ;受体二聚体化与激酶的激活;Binding of insulin to the alpha subunits causes the beta subunits to phosphorylate themselves (