地方性砷中毒对居民免疫功能远期影响的研究.docVIP

PAGE 1 - 地方性砷中毒对居民免疫功能远期影响的研究 摘要：目的 探讨地方性砷中毒对机体免疫功能的远期影响，为砷中毒病区居民的预防和治疗提供科学依据。方法 采用整群抽样和典型调查相结合的方法进行现场调查，改水5年后的砷中毒病区调查者分为轻、中、重度病例组和内对照组，非病区调查者为外对照组。对调查者的免疫功能指标免疫球蛋白G(IgG)和溶菌酶(LSZ)进行测定和分析，并运用SPSS13.0 for windows软件对数据进行统计分析处理。结果 调查5个组共252人，所选择的病区村5年前已实施改水，水砷含量符合国家标准(≤0.05mg/L)，各组尿砷含量无统计学意义差异(H=2.698, P0.05)。各组IgG含量有统计学意义差异(H =52.923，P0.01)，外对照组IgG均数为11.16g/L，含量明显高于其他组别(P0.05)，其他组间比较无统计学意义差异(P0.05)。各组溶菌酶水平有统计学意义差异(H=34.998, P0.01)，外对照组溶菌酶水平为13.57μg/ml，明显高于其他组别(P0.05)，其他组间比较无统计学意义差异(P0.05)。结论 地方性砷中毒患者饮用低砷水5年后砷对机体免疫功能的影响仍然存在，砷中毒病区 关键词：砷中毒；免疫功能；远期影响 Study of the long-term effect of endemic arsenism on immune function of resident. [Abstract] Objective To explore the long-term effect of endemic arsenism on immune function of body, so that providing the evidence for prevention and treatment of resident in the arsenic exposure areas. Methods Using cluster sampling and typical investigation，the subject were divided five groups. Five groups included the slight patient group, the middle patient group, severe patient group, the outer control group and the inner control group. The patient groups and the inner control group were selected in the arsenism areas after 5 years of water mitigation .The immunity indicators were measured and analyzed. Immunity indicators included Gimmunoglobulin G (IgG) and lysozyme(LSZ). The data were analyzed by SPSS13.0 for windows. Results There were altogether 252 people surveyed in five groups. It has been observed that water arsenic of the arsenism areas were below the national drinking water quality level (≤0.05mg/L). Urine arsenic content weren’t significantly different in five groups (H=2.698, P0.05). The concentrations of IgG were significantly different in five groups (H =52.923，P0.01). The average of IgG in outer control group was 11.16g/L.The concentration of IgG in outer control group was significantly higher than that in the other groups (P0.05). The concentrations of IgG weren’t significantly different in the other groups (P0.05)