急性脑梗死病人血清sICAM1与sEselectin含量变化医学.docVIP

急性脑梗死病人血清sICAM1与sEselectin含量变化医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：急性脑梗死病人血清sICAM1与sEselectin含量变化医学 1 1 资料与方法 2 2 结果 3 3 讨论 4 文2：冠心病病人血清OXLDL与sICAM1变化及其意义医学 6 1 对象与方法 7 2 结 果 8 3 讨论 9 参考文摘引言： 11 原创性声明（模板） 13 文章致谢（模板） 14 正文 急性脑梗死病人血清sICAM1与sEselectin含量变化医学 文1：急性脑梗死病人血清sICAM1与sEselectin含量变化医学 ［ABSTRACT］ObjectiveTo investigate the dynamic changes of soluble intercellular adhesion molecule-1 （sICAM-1） and soluble E-selectin （sE-selectin） in acute cerebral infarction. MethodsThe levels of serum sICAM-1 and sE-selectin in 100 cases of acute cerebral infarction on the 1st ， 3rd ， 5th ， and 10th day after the oet and 30 control cases were measured separately using two-layer antibody sandwich enzyme-linked immunosorbent assay （ELISA）. ResultsThe levels of serum sICAM-1 and sE-selec-tin in the patients increased significantly on the 1st day， and reached peak until the 3rd day， followed by obvious reduction after five and 10 days. The levels of sICAM-1 and sE-selectin at all time-point increased significantly compared with the control cases （ F=，;t=;P ）. Larger cerebral infarction induced higher level of serum sICAM-1 and sE-selectin than the medium and small cerebral infarction （ F=，;t=;P ）. ConclusionAcute cerebral infarction increases the levels of serum sICAM-1 and sE-selectin， which is changed with the coue of the disease and closely associated with volume of the infarcted focus. ［KEY WORDS］cerebral infarction; intercellular adhesion molecule; E-selectin 脑梗死是中老年人常见病之一，有较高的致死率及致残率。近年来脑梗死病人半暗区神经细胞损伤与炎症的关系愈来愈受到人们的关注［1］，脑缺血受损部位有白细胞浸润和炎性细胞因子的存在，证明了炎症反应参与了急性脑缺血的神经细胞损伤过程［2］，黏附分子在此过程中起了重要作用。本文观察了急性脑梗死病人血清可溶性细胞间黏附分子-1（sICAM-1）和可溶性E-选择素（sE-selectin）水平的变化，现报告如下。 1 资料与方法 对象及分组 选择2003年1月～2005年1月青岛市中心医 院神经内科及青岛大学医学院附属医院神经内科住院的发病在24 h以内的急性脑梗死病人100例，诊断符合全国第四届脑血管病会议的诊断标准，并经颅脑CT和（或）MRI证实，同时排除自身免疫性疾病、原发感染性疾病、恶性肿瘤、外伤等可能对本研究有影响的疾病。其中男60例，女40例;年龄 48～ 82岁，平均（ ± ）岁，60岁以下病人19例，61～71岁病人56例，71岁以上病人25例。所有急性脑梗死病人于入院第2～3天复查颅脑CT，并参照多田公式计算脑梗死体积（即脑梗死体积=π/6×长×宽×扫描层数