布洛芬对急性上呼吸道感染患儿的退热效果.docVIP

布洛芬对急性上呼吸道感染患儿的退热效果 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：布洛芬对急性上呼吸道感染患儿的退热效果 1 1 资料与方法 2 2 结果 3 3 讨论 4 文2：布洛芬对小儿急性呼吸道感染的退热作用分析 5 1 资料与方法 5 2 结果 6 3 讨论 6 参考文摘引言： 7 原创性声明（模板） 8 文章致谢（模板） 8 正文 布洛芬对急性上呼吸道感染患儿的退热效果 文1：布洛芬对急性上呼吸道感染患儿的退热效果 Antipyretic effectiveness of ibuprofen suspeion in children with acute upper respiratory infection ［Abstract］ Objective:To observe the antipyretic effectiveness of ibuprofen and acetaminophen. Methods: One hundred febrile children, suffered acute upper respiratory infection, were randomized into ibuprofen (56) and acetaminophen (44) groups. Temperature was recorded at , , , , , , , hou after drug administration. Results: The average time for ℃ decrease in the temperature was (110±78) min with ibuprofen veus (119±82) min with acetaminophen. The proportio, respectively, were % and % (P). Temperature normalization times were (110±76) min in the ibuprofen group compared with (124±78) min in the acetaminophen one (P). Temperature normalization rates in the ibuprofen group (%) were significantly higher than the acetaminophen group (%, P). The decline in temperature of two groups was not significantly different during the fit two hou. At , , and hou after the fit dose of treatment, the mean temperature in the ibuprofen group was significantly lower than the acetaminophen group, demotrating longer temperature normalization with ibuprofen. Conclusio: The antipyretic effectiveness of ibuprofen was better than that of acetaminophen. ［Key words］ Ibuprofen; Acetaminophen; Antipyretic effectiveness; Children 布洛芬和对乙酰氨基酚是儿童常用的解热镇痛药，我们对高热患儿分别应用布洛芬混悬液（以下简称布洛芬）与对乙酰氨基酚口服溶液（以下简称对乙酰氨基酚）进行治疗，观察两药的退热效果，现报道如下。 1 资料与方法 一般资料2004年8月～2004年11月有发热症状的急性上呼吸道感染急诊患儿100例，男58例，女42例。治疗前排除下列情况［1］：（1）6个月内有热惊厥史；（2）应用抗生素治疗超过12 h；（3）4 h内已用退热剂；（4）对两种药曾有过敏或不良反应者。治疗过程中未用抗惊厥药、制酸剂、糖皮质激素、非类固醇类抗炎药；亦不使用物理降温方法。随机分为布洛芬组56例，对乙酰氨基酚组44例；平均年龄布洛芬组（±）岁，对乙酰氨基酚组（±）岁（t=，P）；给药前平均体温布洛芬组（±）℃，对乙酰氨基酚组（±）℃（t=，P） 治疗方法布洛芬组给予布洛芬（美林，上海强生制药有限公司，含布洛芬20 mg/mL）5～10 mg/kg口服