高压氧治疗颅脑损伤后抑郁的疗效分析.docVIP

高压氧治疗颅脑损伤后抑郁的疗效分析 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：高压氧治疗颅脑损伤后抑郁的疗效分析 1 1 资料与方法 2 2 结果 4 3 讨论 4 文2：重组生长激素治疗颅脑损伤后胃肠功能障碍的临床研究 6 1 资料与方法 6 2 结果 7 3 讨论 7 参考文摘引言： 8 原创性声明（模板） 9 文章致谢（模板） 9 正文 高压氧治疗颅脑损伤后抑郁的疗效分析 文1：高压氧治疗颅脑损伤后抑郁的疗效分析 Analysis of Therapeutic Effect of Hyperbaric Oxygen on Depression after Craniocerebral Injury Abstract： Objective To discuss the effect of hyperbaric oxygen (HBO) therapy on the daily living activity and depression after craniocerebral All the 76 patients with depression after craniocerebral injury were divided into two groups at random, . HBO group (n=38) and control group (n=38). Both the two groups were treated with routine medication plus guidance of functional rehabilitation. The HBO group was additionally treated with HBO therapy as soon as the disease condition became stable. Barthel index and Hamilton depression rating scale (HAMD) were measured respectively before therapy and after three months Barthel index of the HBO group increased significantly after three months therapy when compared with that of the control group, whereas its HAMD decreased obviously (P).Conclusion Combined HBO therapy can improve the patients daily living activity and depression after they suffer from craniocerebral injury. Key words： craniocerebral injury; depression; hyperbaric oxygen 随着 现代 化的 发展 ，致伤因素也随之增多，颅脑损伤已成为我国创伤中的常见病、多发病。有关资料表明，颅脑损伤患者中约40%留有中、重度残疾[1]。其中抑郁的发生率约30%~48%[2]，严重影响了患者的生活质量，同时也给家庭乃至社会带来负担。高压氧(hyperbaric oxygenation，HBO)是临床常用的物理治疗手段之一，目前临床上脑卒中后抑郁的高压氧治疗疗效屡见报道[3]，但对颅脑损伤后抑郁的高压氧治疗疗效鲜有报道。为探讨高压氧治疗颅脑损伤后抑郁患者近期日常生活活动能力和抑郁心理的疗效，我院对颅脑损伤后抑郁患者进行了高压氧治疗。 1 资料与方法 一般资料 （1）入选标准：有明确的头部外伤史，并经头颅CT或MRI检查确诊颅脑损伤；经用美国流行病调查中心抑郁量表（Center of Epide Miological Survey Depression Scale CESD）检测[4]，得分≥16分，诊断为颅脑损伤后抑郁。（2）排除标准：颅脑损伤后病情严重或伴有意识障碍不能配合检查者；伴有明显失语、认知功能障碍患者；病程2个月以上的颅脑损伤患者；既往有精神障碍个人史或家庭史者。本组病例均为符合上述条件的颅脑损伤后抑郁患者，共76例，其中男56例，女20例；年龄15~67岁，平均（±）岁；病程8 d~2个月，平均（33±12）d；单纯硬脑膜下或硬脑膜外出血9例， 蛛网膜下隙出血及其他。11例，脑挫裂伤56例。随机分成高压氧组和对照组，每组38例，两组基线资料经统计学