围术期C反应蛋白水平与术后低蛋白血症发生的相关性探讨临床医学.docVIP

围术期C反应蛋白水平与术后低蛋白血症发生的相关性探讨临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：围术期C反应蛋白水平与术后低蛋白血症发生的相关性探讨临床医学 1 1 资料与方法 3 2 结果 3 3 讨论 4 文2：C反应蛋白与急性胰腺炎的相关性探讨 6 1资料与方法 7 2 结果 9 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 围术期C反应蛋白水平与术后低蛋白血症发生的相关性探讨临床医学 文1：围术期C反应蛋白水平与术后低蛋白血症发生的相关性探讨临床医学 [Abstract] Objective To explore the relatiohip of perioperative C-reactive protein levels and the incidence of postoperative Between January 2008 and December 2008，133 patients undergoing moderate-larger operatio in the Department of General Surgery were serum C-reactive protein and serum albumin concentratio were measured and analyzed respectively，the Peaon correlation analysis was The postoperative serum C-reactive protein and serum albumin levels，compared with preoperative above-mentioned index proved extremely significantly(P).The postoperative serum albumin levels between the patients with preoperative serum C-reactive protein levels≥10 mg/L and 10 mg/L were different(t=-，P).In the Peaon correlation analysis，a negative correlation was found between postoperative albuminemia and preoperative serum C-reactive protein as well as postoperative serum C-reactive protein(r=-，P;r=-3470，P).A negative correlation was found with preoperative serum C-reactive protein and serum albuminemia(r=-，P).Conclusion Postoperative albuminemia is negatively correlated with preoperative and postoperative serum C-reactive protein，which could be used to predict postoperative infection and evaluate surgeo should pay much more attention to it. [Key words] perioperative period;C-reactive protein;operation;hypoalbuminemia 外科手术后患者由于创伤应激，机体处于高代谢和高分解代谢状态，蛋白质分解代谢增加，丢失增多，常有明显的体重减轻和负氮平衡，使机体处于营养不良状态，加之某些患者术前就已存在不同程度的营养不良，导致组织修复及抗感染能力下降且易出现术后并发症，低血浆白蛋白水平可以作为危险性增高的标志，且与病情及预后密切相关。而C-反应蛋白(C-reactive protein，CRP)是一种急性期反应蛋白，正常人体内含量极少(3 mg/L)，是一种非特异性炎性因子及时相蛋白[1，2]。当机体遭受重大创伤、感染等炎性反应时血液当中CRP会明显升高，由于其敏感性不受性别、年龄等因素的影响，临床上常作为病情恶化或好转的敏感指标。CRP与炎性反应、感染及心脑血管病的相关性报道较多，临床应用广泛，而创伤与CRP的相关性报道较少，其中术后低蛋白血症与之相关性