丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响.docVIP

丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响 文档信息 主题： 关于“医学心理学”中“肿瘤学”的参考范文。 属性： Doc-0292JB，doc格式，正文7431字。质优实惠，欢迎下载！ 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响 1 1 材料与方法 3 2 结 果 4 3 讨 论 5 文2：中医调护对卵巢癌患者化疗的影响 6 1资料和方法 6 2结果 8 3讨论 8 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 11 正文 丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响 文1：丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响 yang gaoyuan， rong fengnian， zhou ting ( department of gynecology and obstetrics， shandong qianfoshan hospital， school of clinical medicine， shandong univeity， jinan 250014， china) to investigate the inhibitory effect of valproic acid（vpa）on angiogenesis of human ovarian cancer in nude mice. methods human ovarian cancer models were established by subcutaneous traplantation in nude mice， and then they were divided into 4 groups: the control group， the vpa group， the cisplatin (ddp) group and the vpa+ddp group. the antitumor efficacy was evaluated by determination of tumor volume， tumor growth and relative tumor curative rate. also expression levels of cd105 and sflk1 were determined by immunocytochemistry (ic). results ① tumor volumes in the experimental groups were smaller than those in the control group; ② expression levels of cd105 in the experimental groups were significantly higher than those in the control group(p＜); and ③ expression levels of sflk1 in the experimental groups were significantly higher than those in the control group(p＜). conclusio vpa can inhibit the growth of ovarian cancer by decreasing the expression of cd105 and increasing the expression of sflk1 levels。 key words： valproic acid； cisplatin； ovarian neoplasms； nude mice 卵巢癌是女性生殖器官的三大恶性肿瘤之一，且早期不易发现，多数患者确诊时已属晚期，因此卵巢癌的预后与化疗关系密切。(valproic acid，vpa)是临床上广泛使用的广谱抗癫痫药，具有抑制组蛋白去乙酰化酶（histone deacetylase，hdac）的作用，能抑制肿瘤血管的形成。vpa因生物利用度较好、毒副作用较低而备受关注［1］。本研究选用人卵巢癌移植瘤裸鼠作模型，观察vpa对肿瘤血管形成的抑制作用，初步探讨其相关机理 1 材料与方法 材料 人卵巢上皮腺癌skov3细胞，由山东大学齐鲁医院中心实验室提供；vpa纯品购自sigma公司；顺铂（cisplatin，ddp）纯品购自山东齐鲁制药厂（批号：dc）；balb/c、 nuu裸小鼠24只，4～6周龄，雌性，体质量18～