成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析.docVIP

成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析 1 1资料和方法 2 文2：成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析医学论文 5 1资料和方法 6 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 11 正文 成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析 文1：成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析 Abstract：Objective To prospectively study the survival of adult patients with grade Ⅱ～Ⅳ cerebral gliomas received radiochemotherapy postoperatively. MethodsFrom sept. 1999 to may 2003， 80 adult postoperative patients with grade Ⅱ～Ⅳ cerebral gliomass were treated and pided into two groups randomly，each had 40 cases. One group(RT group) was irradiated with DT50～60 Gy merely and the other (RCT group) combined with chemotherapy(VM26 and MeCCNU) after DT20 Gy and 4～6 cycles of chemotherapy were delivered within 4～6 months. ResultsThe 1， 3， and 5 year survival rate of patients of RCT group was %、%、% while the survival rate of RT group was %、%、%， respectively. The difference of the survival rates between two groups was significant（χ2=，P=）. Based on pathological grades，however，it was suggested that only the patients with grade Ⅲ gliomas of RCT group had better prognosis than ones of RT group (χ2=， P=).The similar results were not found in patients with grade Ⅱ or Ⅳ gliomas. ConclusionGiven concurrent radiochemotherapy postoperatively， the survival could be improved in adult patients with grade Ⅲ gliomas. And the data suggested that VM26 combined with MeCCNU should be an effective chemotherapeutic scheme. AS to grade Ⅳ gliomas， more novel chemotherapeutic methods shoud be studied. The patients with grade Ⅱ gliomas needn’t receive chemotherapy besides postoperative radiotherapy。 Key words：Cerebral glioma;Radiotherapy;Chemotherapy 0引言 原发性脑肿瘤中约60%为胶质瘤，脑胶质瘤治疗首选手术，但对于病理分级Ⅱ级以上肿瘤，往往由于难以彻底切除而需要辅助放化疗，以提高疗效。目前，Ⅱ级胶质瘤术后放疗后是否需要联合化疗仍有争论，而Ⅲ、Ⅳ级胶质瘤大多主张术后放化疗，但术后放疗时机、化疗药物的选择以及放化疗联合方式尚无定论。1999年9月～2003年5月间我院收治Ⅱ级以上脑胶质瘤术后成人患者80例，给予单纯术后放疗或同步放化疗联合治疗，以观察不同病理分级脑胶质瘤术后联合放化疗的疗效。 1资料和方法 入组条件及分组 ①经手术肉眼全切，或部分切除肿瘤者；②术后病理诊断为胶质瘤Ⅱ、Ⅲ或Ⅳ级；③Karnofsky评分≥60分；④年龄18周岁以上