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Foundations of Genetics
Mendel’s Law
1. Theories of inheritance
• Early ideas of inheritance included the theory of
pangenesis 泛生论 and August Weismands germ
plasm theory 种质学说.
• Based on experiments with mice, Weismann
proposed that hereditary information in gametes
transmitted traits to progeny.
• Both of these early views incorporated the
blending theory : they held that heritable traits of
the two parents blend, so that the distinct
characteristics of each are lost in offspring.
Pangenesis 泛生论
• The word comes from the Greek words pan (a prefix meaning
whole, encompassing) and genesis (birth)
or genos (origin).
• The pangenesis theory, proposed by Darwin, similarly
to Hippocratess views on the topic, imply that the whole of Hippocrates
parental organisms participate to heredity—thus the prefix
pan--, while adapting to cell theory.
• Much of Darwins model was speculatively based on
inheritance of tiny heredity particles he called gemmules 泛粒
子that could be transmitted from parent to offspring.
• Darwin emphasized that only cells could regenerate new
tissues or generate new organisms. He posited that atomic
sized gemmules formed by cells would diffuse and aggregate in
the reproductive organs.
Darwin
Germ plasm theory 种质学说
• The term germ plasm was first used by the German
biologist August Weismann.
• Germ plasm theory states that multicellular organisms consist
of germ cells that contain and transmit heritable information,
and somatic cells which carry out ordinary bodily functions.
• In the germ plasm theory, inheritance in a multicellular
organism only takes place by
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