医学微生物学课件：8-10 肠道致病菌.pptx

Tuberculosis;Enteric Gram-negative rods (Enterobacteriaceae) (肠杆菌科) Escherichia (埃希菌属) Salmonella (沙门菌属) Shigella (志贺菌属) Vibrio (弧菌属) V. cholerae (霍乱弧菌) V. parahemolyticus (副溶血性弧菌) Helicobacter (螺杆菌属) and Campylobacter (弯曲菌属) Helicobacter pylori, HP(幽门螺杆菌) Campylobacter jejuni (空肠弯曲菌);G－ rods, in irregular pili, most have flagellum (besides Shigella) Ag---O, H, K (Vi) Biochemical reaction: identification Most are normal flora in intestine tract, few are pathogens variation: drug resistance， H-O, S-R;;; O (lipopolysaccharide )Ag —— somatic Ag(菌体Ag) H (flagellar) Ag——鞭毛Ag K Ag Vi Ag;;E.coli ⊕ ⊕ - + Shigella + - - - S.typhi + - -/+ + Other Salmonella ⊕ - +++ + ;Sec.1 Escherichia 埃希菌属;;The Numbers of E. Coli flora (大肠菌群数)： ≤3个/L drinking water ≤5个/100ml, soda pop, juice Total number of bacteria: ≤100个/ml drinking water;Infection out of intestine tract (normal flora, endogenic infection, 内源性感染) Urinary tract infection, pyogenic infection, septicemia hemolysin/K Ag/P pili Molecular biology and genetic engineering ;Diarrhea (pathogenic, exogenous infection) ETEC--LT,ST--infant/traveler’s diarrhea EIEC--pili—resembles shigellosis, bloody and pus feces (痢疾样脓血便) EPEC—adherence— watery diarrhea in infants EHEC(O157:H7)--pili,SLT—hemorrhagic colitis, hemolytic-uremic syndrome, HUS(溶血性尿毒综合征) EAggEC—toxin,pili—infant acute and chronic diarrhea in infants (婴儿持续性腹泻) ; travellers diarrhea/infants diarrhea milder → diarrhea like cholera (霍乱样腹泻) pathogenic materials： colonization factor(定植因子) Enterotoxin;Heat labile enterotoxin, LT A: enter into cell→cAMP↑→hypersecretion B: attaches to the GM1 ganglioside Heat stable enterotoxin, ST →cGMP↑→hypersecretion;is a common cause of “traveler‘s diarrhea” and a very important cause of diarrhea in infants