缺氧复氧性损伤对培养海马细胞ICAM1表达影响及银信达莫的保护作用（医疗卫生论文资料）.docVIP

缺氧复氧性损伤对培养海马细胞ICAM1表达影响及银信达莫的保护作用（医疗卫生论文资料） 文档信息 ： 文档作为关于“医学心理学”中“医学研究方法”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文8381字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：缺氧复氧性损伤对培养海马细胞ICAM1表达影响及银信达莫的保护作用 2 1 材料与方法 3 2 结果 5 3 讨论 5 文2：悦肝胶囊对四氯化碳损伤原代培养大鼠肝细胞的保护作用 7 1 材料 8 2 方法 8 3 结果 9 4 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 缺氧复氧性损伤对培养海马细胞ICAM1表达影响及银信达莫的保护作用（医疗卫生论文资料） 文1：缺氧复氧性损伤对培养海马细胞ICAM1表达影响及银信达莫的保护作用 The effects of hypoxia reoxygenation induced injury on the expression of ICAM-1 in hippocampal neuron cells in culture and the protective function of YinXinDaMo GU Jian-jun， GAO Guang-zhong， LU Jun， ZHANG Qin， JIANG Lin， LIU Xiao-xing， WANG Xiao-lin， YIN Rong-jian， YIN Chun (Department of Neurosurgery， Taizhou Peoples Hospital Affiliated to Nantong Univeity， Taizhou， Jiangsu 225300， China) Abstract: Objective To investigate injury induced by hypoxia reoxygenation impacts on the expression of ICAM-1 in hippocampal neuron cells in culture and the protective function of YinXinDaMo. Methods The SD rats were allocated to a normal culture group， hypoxia reoxygenation alone group (HR group)， a hypoxia reoxygenation+YinXinDaMo group， 6-hour reoxygenation following 1-hour hypoxia. The measurements of ICAM-1 levels， cytoplasmic free calcium ([Ca2+]i)， nitric oxide synthase (NOS)， superoxide dismutase (SOD)， malonyl dialdehyde (MDA) and reduced glutatione form (GSH) were recorded. Results When stimulated by hypoxia reoxygenation， the elevated levels of ICAM-1， [Ca2+]i and MDA were obtained in hippocampal neuron cells， and SOD， GSH， NOS decreased significantly. YinXinDaMo could obviously improve the expression of ICAM-1 in hippocampal neuron cells with hypoxia reoxygenation， and also could inhibit the MDA， [Ca2+]i overload and the decrease of SOD， GSH， NOS. Conclusion Hypoxia reoxygenation directly or indirectly activated ICAM-1 to induce hippocampal neuron cells injury， but Ca overload， oxygen free radicals and NOS system