便秘（英文）课件.pptxVIP

Cleveland Clinic;Outline;Normal Defecation;Incidence;Constipation: Rome III Criteria;Etiology of Constipation;Chronic Idiopathic Constipation;Pathophysiology of Slow-Transit Constipation ? Structurally normal colon and rectum ? Blunted gastrocolic response to meals ? Reduced colonic response to morning waking ? Impaired phasic colonic motor activity 一 Decreased HAPCs—velocity, frequency, amplitude ? Increased periodic rectal motor activity ? Paucity of interstitial cells of Cajal ? Decreased level of motilin ? Concurrent upper Gl motility disorder (77%);Detailed History;Factors Suggestive of S