点击化学PPT课件.ppt

Literature Review ; The term Click Chemistry was introduced by Sharpless and coworkers and is defined as a reaction that is modular, wide in scope, high in yield, has little side products that are easily removed by non-chromatographic methods ，is stereospecific but not necessarily enantioselective, uses simple reaction conditions, is not sensitive to oxygen or water, uses easily accessible reagents, requires no solvent or a solvent that is easily removed or benign like water, enables simple product isolation, has a high thermodynamic driving force and goes rapidly to completion.;The marriage of click chemistry with polymer science;Enhanced Efficiency;Enhanced Specificity/Orthogonality;叠氮-炔基环加成反应（Azide–Alkyne Cycloaddition） ;Proposed mechanism for the CuI-catalyzed cycloaddition by Sharpless and coworkers;General Method for Convergent Dendrimer Synthesis via CuAAC;Modular approach of synthesizing block copolymers, stars, and graft copolymers by click chemistry.;Polymer-protein conjugates prepared by copper-catalyzed azide-alkyne cycloaddition of alkyne- or azide-labeled proteins with polymers bearing the complementary functionality.;RAFT and click chemistry;ATRP and click chemistry;力引发的的叠氮-炔基偶合反应（Strain-Promoted Azide-Alkyne Coupling）;力引发的的叠氮-炔基偶合反应（Strain-Promoted Azide-Alkyne Coupling）;狄尔斯-阿尔德环加成（ Diels-Alder Cycloaddition） ; Orthogonal One-Pot Synthesis of ABC Triblock Copolymers by Simultaneous Diels-Alder and Copper-Catalyzed Azide-Alkyne Cycloaddition.; Hetero-Diels-Alder Reactions of Dienes and Thiocarbonylthio-Terminated Polymers Prepared by Reversible Addition-Fragmentation Chain Transfer Polymerization.;硫醇-烯反应（Thiol-Ene Reactions ）;Thiol- Ene and RAFT; Challenges; Challenges;Thank you !