医学微生物学：第10章 螺杆菌属和弯曲菌属.pptVIP

MAJOR FOODBORNE DISEASES FROM MICROORGANISMS Infections due to enterohaemorrhagic (causing intestinal bleeding) E. coli, e.g. E.coli O157, and listeriosis are important foodborne diseases which have emerged over the last decades. Although their incidence is relatively low, their severe and sometimes fatal health consequences, particularly among infants, children and the elderly, make them among the most serious foodborne infections. Cholera is a major public health problem in developing countries, also causing enormous economic losses. The disease is caused by the bacterium Vibrio cholerae. In addition to water, contaminated foods can be the vehicle of infection. Different foods, including rice, vegetables, millet gruel and various types of seafood have been implicated in outbreaks of cholera. Symptoms, including abdominal pain, vomiting and profuse watery diarrhoea, may lead to severe dehydration and possibly death, unless fluid and salt are replaced. 关键问题 简述幽门螺杆菌的主要生物学特性及致病物质及所致疾病。 第十章 螺杆菌属和弯曲菌属 第一节 螺杆菌属 第二节 弯曲菌属 Marshall BJ,?Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet.?1984 Jun 16;1(8390):1311-5. Abstract Biopsy specimens were taken from intact areas of antral mucosa in 100 consecutive consenting patients presenting for gastroscopy. Spiral or curved bacilli were demonstrated in specimens from 58 patients. Bacilli cultured from 11 of these biopsies were gram-negative, flagellate, and microaerophilic and appeared to be a new species related to the genus Campylobacter. The bacteria were present in almost all patients with active chronic gastritis, duodenal ulcer, or gastric ulcer and thus may be an important factor in the aetiology of these diseases. Lancet.?1988 Dec 24-31;2(8626-8627):1437-42. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Marshall BJ,?Goodwin CS,?Warren JR,?Murray R,?Blincow ED,?Blackbourn SJ,?Phillips M,?Waters TE,?Sanderson