CSU-BPH良性前列腺增生临床指南.pptVIP

1）非那雄胺适用于治疗有前列腺体积增大伴下尿路症状的BPH患者。 2）非那雄胺缩小前列腺体积达20%-30%，改善症状评分约15%，提高尿流率约1.3-1.6ml/s，降低急性尿潴留和手术干预的风险50%左右，同时降低BPH患者血尿的发生率和前列腺癌的发生率(PCPT)。 3）非那雄胺最常见的副作用包括勃起功能障碍、射精异常、性欲低下和其它如男性乳房女性化、乳腺痛等。 4）非那雄胺能降低血清PSA的水平，服用非那雄胺每天5mg持续1年可使PSA水平减低50%。 5α还原酶抑制剂的疗效 This is the pathophysiplogy of symptoms of BPH. Bladder outlet obstruction (BOO) is the primary mechanism. There are two obstructions, dynamic and static obstruction. Hyperactivity of sympathetic nerve system and enlarged volume of prostate contribute to each obstruction, respectively. Both obstructions equally contribute to LUTS of BPH. In addition,