依达拉奉治疗老年急性脑出血的疗效及对患者血清HMGB 1CRP表达的影响.docxVIP

依达拉奉治疗老年急性脑出血的疗效及对患者血清HMGB 1CRP表达的影响 依达拉奉治疗老年急性脑出血的疗效及对患者血清hmgb-1、crp表达的影响 　　【摘要】目的：探讨依达拉奉治疗老年急性脑出血的疗效及对患者血清高迁移率族蛋白-1（hmgb-1）、c反应蛋白（crp）表达的影响。方法：收集2017年1月-2019年2月本院收治的73例脑出血患者，采用随机数字表法分为治疗组37例与对照组36例。对照组给予神经内科常规综合治疗，治疗组加用依达拉奉治疗，两组疗程均为14d。比较两组治疗前后神经功能，血清hmgb-1、crp表达含量变化情况，并评估疗效。结果：治疗后，治疗组nihss评分低于对照组，血清hmgb-1、crp表达含量均低于对照组（p0.05）;治疗组与对照组总有效率分别为91.89%、72.22%，治疗组高于对照组，差异有统计学意义（p0.05）。结论：依达拉奉治疗老年急性脑出血的疗效确切，可明显改善神经功能，并下调血清hmgb-1、crp表达。 　　【关键词】依达拉奉急性脑出血神经功能c反应蛋白 　　efficacyofedaravoneinthetreatmentofacutecerebralhemorrhageinelderlypatientsanditseffectonserumhmgb-1andcrpexpression/wangxinli.//medicalinnovationofchina，2020，17（09）：0-060 　　[abstract]objective：toinvestigatetheeffectofedaravoneinthetreatmentofacutecerebralhemorrhageinelderlypatientsanditseffectonserumhighmobilitygroupboxprotein-1（hmgb-1）andcreactiveprotein（crp）expression.method：seventy-threepatientswithcerebralhemorrhageadmittedtoourhospitalfromjanuary2017tofebruary2019wereenrolled.thepatientsweredividedintothetreatmentgroup（n=37）andthecontrolgroup（n=36）byrandomnumbertable.thecontrolgroupwasreceivedroutinecomprehensivetreatmentofneurology，andthetreatmentgroupwastreatedwithedaravone，thecourseoftreatmentinbothtwogroupswas14days.theneurologicalfunction，serumhmgb-1andcrpexpressionlevelsoftwogroupsbeforeandaftertreatmentwerecompared，andtheefficacyoftwogroupswasevaluated.result：aftertreatment，thenihssscoreofthetreatmentgroupwaslowerthanthatofthecontrolgroup，andtheserumhmgb-1andcrpexpressionlevelswerelowerthanthoseofthecontrolgroup（p0.05）.thetotaleffectiverateofthetreatmentgroupandthecontrolgroupwere91.89%and72.22%，respectively，thetreatmentgroupwashigherthanthatofthecontrolgroup（p0.05）.conclusion：edaravoneiseffectiveinthetreatmentofacutecerebralhemorrhageinelderlypatients，whichcansignificantlyimprovetheneurologicalfunctionanddown-regulatetheexpressionofserumhmgb-1andcrp. 　　[keywords]edaravoneacutecerebralhemorrhageneurologicalfunctioncreactiveprotein 　　first-author’saddress：jiamusimaternalan