核医学教学课件：PETMRI Clinical Research Routine.pptVIP

PET/MRI Clinical Research Routine Klinikum rechts der Isar der Technischen Universit?t München PET/MR systems open many new exciting possibilities for clinical as well as research appilications, e.g. by using different MR-applications (DWI, DCE, MRS) combined with a variety of different PET-Tracers different methods software fusion different scanner systems PET/MRI Clinical Research Application PET or PET/CT side-by-side to a MRI in the next room (“Shuttle system”) No scanner modifications necessary Established technology Not truly “PET/MR”, elaborate retrospective fusion Sequential PET/MR, similar to PET/CT Few scanner modifications, basically established PET and MRI technology Not simultaneous Rather large footprint PET-insert for clinical MRI Very flexible solution New PET detector technology Only limited FOV (brain studies) Fully integrated whole-body PET/MR Truly simultaneous MRI and PET acquisition Most complex approach, new PET detector technology Combination of PET and MRI: different approaches MRI PET PET/MR Fully integrated hybrid whole-body PET/MR Replacement of photomultiplier tubes by avalanche photodiodes (APDs) Set-up of Biograph mMR: PET detectors 8 rings with 56 detector blocks each (? = 65.6 cm) Each detector block contains a matrix of 8 x 8 LSO crystals (4 x 4 x 20 mm3) Crystal read-out by an array of 3 x 3 APDs PET attenuation correction 18F-FDG PET non attenuation corrected Attenuation Correction Standalone PET PET/CT MR/PET ? 18F-FDG PET attenuation corrected MR-based attenuation correction: DIXON imaging PET NAC PET AC μ-map fat image water image in phase opposed phase Neurology / Neurooncology and Cardiology: PET one bed position, exam time mainly defined by MRI Oncology: Patient presents with staging exams (CT, …): specific questions for PET/MR PET (partial) whole body, MRI focuses on specific area of interest (e. g. liver) Patient presents without extensive previous imaging data / follow-up / restaging: full diagnostic c