替比夫定阻断乙肝病毒母婴传播的有效性及安全性评价.docxVIP

替比夫定阻断乙肝病毒母婴传播的有效性及安全性评价 　　【摘要】目的：观察与分析替比夫定阻断乙肝病毒母婴传播的有效性及安全性。方法：选取2017年5月-2018年10月本院收治的160例hbsag阳性孕妇为研究对象，根据治疗方案的不同分为对照组和试验组，各80例。对照组采用常规干预，试验组采用替比夫定+常规干预。比较两组孕妇治疗前及分娩前、分娩后4周、24周的hbv-dna、alt及ck-mb水平、不良妊娠发生率、剖宫产率及产后出血率，同时比较两组新生儿感染率、胎龄、体质量、身长、头围及apgar评分。结果：分娩前和分娩后4、24周，试验组孕妇的hbv-dna均低于对照组，新生儿感染率低于对照组（p0.05）。两组alt、ck-mb水平、不良妊娠发生率、剖宫产率及产后出血率比较，差异均无统计学意义（p0.05）;两组新生儿胎龄、体质量、身长、头围及apgar评分比较，差异均无统计学意义（p0.05）。结论：替比夫定阻断乙肝病毒母婴传播的有效性及安全性均较高，因此应用价值较高。 　　【关键词】替比夫定阻断乙肝病毒母婴传播有效性安全性 　　[abstract]objective：toobserveandanalyzetheeffectandsafetyoftebivudineintheblocktransmissionofmother-to-childtransmissionofhepatitisbvirus.method：atotalof160pregnantwomenwithhbsag-positiveinourhospitalfrommay2017tooctober2018werechosenasthestudyobjects，andtheyweredividedintothecontrolgroupandtheexperiencegroup，accordingtothetreatmentmethods，80casesineachgroup.routineinterventionwasusedinthecontrolgroupandtibivudine+routineinterventionintheexperimentalgroup.thenthehbv-dna，altandck-mblevelsbeforethetreatment，beforedelivery，4weeksand24weeksafterdelivery，incidenceofadversepregnancy，cesareansectionrateandpostpartumhemorrhagerateofpregnantwomenintwogroupswerecompared，andtheinfectionrate，gestationalage，bodyweight，length，headcircumferenceandapgarscoreofnewbornsintwogroupswerecompared.result：thehbv-dnaofpregnantwomenintheexperiencegroupbeforedelivery，4weeksand24weeksafterdeliverywerelowerthanthoseofthecontrolgroup，theinfectionrateofnewbornswaslowerthanthatofcontrolgroup，therewerestatisticallysignificantdifferences（p0.05）.thealtandck-mblevels，incidenceofadversepregnancy，cesareansectionrateandpostpartumhemorrhagerateoftwogroupswerecompared，therewerenostatisticallysignificantdifferences（p0.05），thegestationalage，bodyweight，length，headcircumferenceandapgarscoreofnewbornsintwogroupswerecompared，therewerenostatisticallysignificantdifferences（p0.05）.conclusion：theeffectandsafetyoftebivudineintheblocktransmissionofmother-to-childtransmissionofhepatitisbvirusishigher，sotheapplicationvalueishigher.[keywords]te