医学免疫学课件：NK细胞与免疫记忆.pptxVIP

我们毕业啦 其实是答辩的标题地方;;Natural Killer Cell Innate lymphocytes develop in bone marrow differentiate by microenvironment 10-15% in PB, 30% in liver no gene rearranged receptor null cell ;;;;;;Hapten-Induced;MCMV-Induced;;;MCMV-Induced;Cytokine-Induced;Cytokine-Induced;; NK cell against virus HCMV、EB virus、 HHV 、 VZV 、HPV HCMV infected NKG2C+NK cell Proliferation and last for 250d 80% in PB; General immune response Influenza vaccine IFN-γ enhanced after vaccination;;Farag S S, Caligiuri M A. Farag SS, Caligiuri MA. Human natural killer cell development and biology. Blood Rev 20: 123-137[J]. Blood Reviews, 2006, 20(3):123-37. OLeary, J.G., et al., T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol, 2006. 7(5): p. 507-16. Cooper MA, Elliott JM, Keyel PA, et al. Cytok ine-induced memory-like natural killer cells [J]. Proc Natl Acad Sci USA, 2009, 106(6):1915-1916. Paust S, Gill HS, Wang BZ, et al. Critical role for the chemokine receptor CXCR6 in NK cell mediated antigen-specific memory of haptens and viruses [J]. Nat. Immunol, 2010, 11:1127–1135. Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection [J]. J. Exp. Med., 2014, 211:2669–2680. Karo JM, Schatz DG, Sun JC. The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells [J]. Cell, 2014, 159:94–107. O Sullivan, T.E., J.C. Sun and L.L. Lanier, Natural Killer Cell Memory. Immunity, 2015. 43(4): p. 634-645.;Martinet, L. and M.J. Smyth, Balancing natural killer cell activation through paired receptors. Nat Rev Immunol, 2015. 15(4): p. 243-54. Artis D, Spits H. The biology of innate lymphoid cells. Nature. 2015; 517:293–301. Morvan M G, Lanier L L. NK cells and cancer: you can teach innate cells new tricks.[J]. Nature Reviews Cancer, 2015, 16(1):7-19. Kamimura Y, Lanier LL. Homeostatic control of memory cell progenitors in the natural killer cell lineage. Cell reports. 2015