医学免疫学课件：IL-12家族及其对T细胞的调节.pptxVIP

IL-12 Family in T Cell Response;Introduction IL-12 Structure of IL-12 and IL-12R Signaling pathway Relevant research IL-23 Structure Function mechanism IL-27 Structure Function mechanism IL-35 Introduction Receptor Clinical research Review prospect ;Introduction;Teng M W L, Bowman E P, McElwee J J, et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases[J]. Nature medicine, 2015, 21(7): 719-729. ;IL-12: Signaling pathway;IL-12: Action on T cells;STAT4 knockout mice Impaired IFN-γ production and Th1 differentiation IL-12: only activator of STAT4 in mice Mice deficient in p35, p40 or Rβ1 Similar phenotypes Show no developmental abnormalities Enhanced Th2 and IL-4 ;Prediction Type 1 inflammatory responses Th1 cell differentiation Activation of STAT Method Cytokine responses in splenic lymphocytes L. monocytogenes Result Analysis IL-12-dependent Th1 response ;In our modern society/In these few years... energy problem has been discussed by a lot of people. Some blabla...others blabla... I believe that....;IL-12: Relevant research;IL-23: Introduction;IL-23: Structure;;IL-23: In Th17 differentiation;Functional maturation Effecter differentiation Acquisition of inflammatory phenotype Stabilization of lineage Repression of alternate effector fates Experimental evidence Material: mice with EAE System: IL-23R deficiency to Tcells Results Arrested Th17 cells differentiation Unable to downregulate IL-2 Unable to proliferate and migrate optimally ; ;IL-23: In nTh17 development;IL-27: Structure; ;IL-27: In Th1 responses;IL-27: In Th17 responses;IL-27: In Th17 responses;IL-27: In Tregs;IL-27: In CD8+ T Cell;IL-35: Introduction;IL-35: Receptor;IL-35: Clinical research;IL-35: Clinical research;IL-35: Clinical research;IL-35: Clinical research;IL-35: Clinical research;IL-35: Clinical research; IL-35 enhanced the suppressive function of Treg cell The CFSE histogram from one representative