Cortistatin-14-human-rat-CST-14-human-rat-DataSheet-生命科学试剂-MedChemExpress.pdf免费

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Cortistatin 14, human, rat Cat. No.: HY-P1212 CAS No.: 193829-96-8 Synonyms: CST-14, human, rat 分⼦式: C₈₁H₁₁₃N₁₉O₁₉S₂ 分⼦量: 1721.01 Sequence: {Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser} {Cys}{Lys} (Disulfide bridge: Cys2-Cys13) Sequence Shortening: PCKNFFWKTFSSCK (Disulfide bridge: Cys2-Cys13) 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Cortistatin 14, human, rat (CST-14, human, rat) 是⼀种具有神经抑制和睡眠调节特性的神经肽，能与 5 种克隆 ⽣长抑素受体 (SSTRs) 和⽣长激素释放肽受体结合，发挥其⽣物学活性，并与⼤脑⽪层和海马内的 GABA 共存 [1] [2]。 REFERENCES [1]. Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767. [2]. de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. McePdfHeight Caution: Product has not been fully