CNS退行性疾病药课件.pptVIP

Chapter 17;Teaching goals;【 Classification 】;§1 Antiparkinsonians 抗帕金森病药 ; The disease is usually characterised by four major clinical features: resting tremor (静止性震颤) muscle rigidity (肌肉强直) bradykinesia (运动迟缓) disturbance of posture (共济失调);直观表现： 面具脸(‘mask-like’ facial expression)、小写症 慌张步态 ( festinating gait )、流涎 ( salivation );7;临床上根据病因不同分为：;黑质;ACh;Treatment (治疗) ：;Ⅰ 拟多巴胺类药;2. 99% of L-dopa is decarboxylated (脱羧) to DA in the periphery (外周) (liver) .; L-dopa;【Action】;3. It is ineffective to the parkinson