课程设计：年产20吨无菌化学原料药美罗培南的车间工艺设计（还原工段）（完整版）.doc

年产20吨无菌化学原料药美罗培南的车间工艺设计(还原工段) 摘 要 美罗培南(meropenem)是一种抗菌活性强、抗菌谱广、对β-内酰胺酶以及I型肾脱氢肽酶耐受性好的新型β-内酰胺类抗生素，属于碳青霉烯类下，该类药物在我国具有广泛的市场前景。本次设计主要为还原工段，通过查阅相关文献确定了美罗培南的还原工段的工艺合成路线。该工艺路线为以缩合物、四氢呋喃、钯炭、甲醇、氢气等为原料，进行还原反应、减压蒸馏、大孔树脂吸附、浓缩、析晶、干燥，得到美罗培南(三水化合物)粗品。 根据设计依据、工艺要求、自然条件,本设计对厂址的选择进行了严密的考虑，在设计过程中对该工艺的物料和能量进行衡算达到平衡，最后根据工艺计算结果进行设备选型得出选型结果一览表，使用Auto-CAD软件分别画出车间布置图以及工艺流程图。 关键词: 美罗培南 工艺设计设备选型Auto-CAD I Annual output of 20 tons of sterile chemical API meropenem’s workshop process design (restore section) Abstract Meropenem is a kind of strong antibacterial activity, wide antimicrobial spectrum, the beta lactamase and type I kidney dehydrogenation peptidase tolerance good new beta lactam antibiotics, belongs to the hydrocarbon enzyme alkenes. The drug has a broad market prospect in our country. This design is mainly to restore the section, through access to relevant literature to determine the synthesis route of meropenem to restore the section. The process route to condensates, tetrahydrofuran, palladium carbon, methanol and hydrogen gas as raw material, reduction reaction, distillation, macroporous resin adsorption, concentration, crystallization, drying and meropenem trihydrate) crude product. According to the design basis, process requirements and natural conditions, the design for site selection were close consideration, in the design process to the process of material and energy to balance count to achieve balance, finally according to the process of the calculation results to select the equipment that selection result summary table, Auto CAD software were painted in the workshop layout and process flow diagram. Key words:Meropenem Process design Equipmentselection Auto-CAD II 目录 前言 1 第1章 课题研究背景与价值 .............................. 2 第1.1节选题的意义与价值 ........................... 2 第1.2节研究综述 ................................... 2 第1.3节课题的研究意义与目的........................ 3 第1.4节研究范围与内容 ............................. 4 第1.5节研究视角与方法 ............................. 4 第2章 概述 ..........