HE-3286-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE HE 3286 Cat. No.: HY-108039 CAS No.: 1001100-69-1 分⼦式: C₂₁H₃₀O₃ 分⼦量: 330.46 作⽤靶点: NF-κB 作⽤通路: NF-κB 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 HE 3286 是天然抗炎类固醇 β-AET 的合成衍⽣物。HE 3286 是具有⼝服活性的 NF- κB 部分抑制剂。HE 3286 降低了促炎信号，包括 IL-6 和基质⾦属肽酶 3。HE 3286 可⾃由穿过⼩⿏⾎脑屏障。HE 3286 可⽤于溃疡性结 肠炎、关节炎、实验性⾃⾝免疫性脑脊髓炎的研究 [1] [2] [3]。 IC50 Target NF-κB [3] 体外研究 HE 3286 attenuates NF-κB phosphorylation, but not influences IκB phosphorylation of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages [3]. HE 3286 (100 nM, overnight) partially blocks the activation of IKK, JNK, p38, and ERK of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages [3]. Western Blot Analysis [3] Cell Line: LPS-induced murine macrophages Concentration: 100 nM Incubation Time: overnight Result: Attenuated NF-κB phosphorylation. Blocked the activation of IKK, JNK, p38, and ERK partially. 体内研究 HE 3286 (25-50 mg/kg; oral gavage; daily for 22-49 days) reduces joint inflammation, synovial proliferation,