EGFR-IN-46-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE EGFR-IN-46 Cat. No.: HY-144794 CAS No.: 2764772-88-3 分⼦式: C₂₇H₃₂F₃N₃O₃ 分⼦量: 503.56 作⽤靶点: Apoptosis; EGFR; FAK 作⽤通路: Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 EGFR-IN-46 是⼀种有效的 EGFR 和 FAK 双重抑制剂，IC50s 分别为 20.17 nM，14.25 nM。EGFR-IN-46 显著抑 制癌细胞的⽣长。EGFR-IN-46 诱导细胞凋亡 (apoptosis)sup[1]。 IC50 Target EGFR FAK 20.17 nM (IC50) 14.25 nM (IC50) 体外研究 EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 µM, respectively [1]. EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells [1]. EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+) [1]. Cell Proliferation Assay [1] Cell Line: DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells Concentration: 10 µM Incubation Time: 24 h Result: Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89