Epithelial tissue 课件 资料 文献.pptVIP

* (1) Tight junction Around apex of the cell Belt-like, barrier junction Provides close apposition of adjacent plasma membranes and occludes the intercellular space Intercellular space TJ proteins Cell 2 Cell 1 紧密连接 (1) Tight junction Function: prevents diffusion of material between intercellular space and lumen of organ BM Endothelium of capillary Lumen Lumen Tight junction Tight junction Gap: filaments with medium electron density On the cytoplasmic surfaces: Numerous actin filaments Electron-dense plaques Terminal web (2) Adhesive junction (adhesion belt) Intercellular space Cell 2 Cell 1 Cadherin Actin filaments Plaque Actin filaments Function: adhesion; support the shape of cells; (3) Desmosome Disk-like junctions Interval: Filaments with low electron density Intermediate line Paired similar structures in adjacent cells: Attachment plaque Intermediate filament (10 nm) 桥粒 角蛋白丝 Cell 1 Cell 2 Function: strong mechanical junction, provide firm connection, e.g. in skin and esophagus (cytokeratin 角蛋白) Intermediate filaments Intermediate line Cell membrane Attachment plaque (4) Gap junction Connexons: Six transmembrane proteins, connexins A central canaliculum, ? 2 nm. Membrane interval: 2-3 nm 缝隙连接 连接蛋白 连接小体 Function: Provide metabolic and electrical continuity (coupling) via the central canaliculi between cells For small molecules, e.g. glucose, amino acid, ions, etc. Communication junction 通讯连接 Junctional complex (1) Basement membrane 3. On the basal surface A thin sheet-like structure between epithelium and connective tissue LM: pink in HE staining 基底膜 Functions: - Provide support and attachment for epithelial cell - Selective diffusion barrier - Mediate cell migration and differentiation Hemidesmosome Reticular lamina Lamina lucida Lamina densa Basal lamina BM Collagen type IV, Laminin, Heparin sulfate 硫酸肝素, etc. 胶原蛋白 层粘连蛋白 Epithelial cells Fibroblasts EM: (1) Basement membrane 透明层 致密层 基板 网板