神经退行性疾病干细胞移植治疗目前研究现状与未来展望.pdfVIP

神经退行性疾病干细胞移植治疗 目前研究现状与未来展望 胎儿神经干细胞治疗帕金森氏病临床研究发展历程 Timeline of landmarks in neural transplantation in PD 1980 1990 2000 2010 1998 2006~2007 ・ .2)12 Generation of iPSC methods Akst hESC-derrved first descnbed TRANSEURO cd I lines transplants scheduled 1988 1992-1999 2001,2003 2010 First f\/M grafts Positn/G results Double-blind fVM TRANSEURO p«rfomed from several open­ graft Inals negatrve begins label trials first reports GIDS Evans JR, Mason SL, Barker RA Prog Brain Res、2012;200:169-98 Transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein- positive Lewy bodies in grafted neurons Lindvall 0, et a/,Nat Med、2008 May;14(5):501-3 A Grafted nigral neurons were found to have Lewy body-like inclusions14 years after transplantation into the striatum of an individual with PD Synuclfein-Host ein-Grafted Neurons UbiquintinnGrafted Newons : Olanow CW、 et al Nat Meds 2008May;14(5):504-6s Transplanted dopamine ne