D-Ala2-Leu-Enkephalinamide-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE [D-Ala2] Leu-Enkephalinamide Cat. No.: HY-P3549 CAS No.: 65189-64-2 分⼦式: C₂₉H₄₀N₆O₆ 分⼦量: 568.66 Sequence Shortening: Y-{d-Ala}-GFL-NH2 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 [D-Ala2] Leu-Enkephalinamide 是⼀种脑啡肽类似物。[D-Ala2] Leu-Enkephalinamide 具有良好的⾓膜通透性 和镇痛作⽤。[D-Ala2] Leu-Enkephalinamide 可⽤于眼部疾病的研究。 体外研究 [D-Ala2] Leu-Enkephalinamide (MEA) (1.0 mM; 10-240 min) has great corneal permeability in vitro [1]. 体内研究 D-Ala2-Leu-enkephalinamide (s.c.) is also enhanced in morphine-dependent animals [2]. REFERENCES [1]. V P Ranta, et al. Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection II. Application to ocular permeability studies in vitro. J Chromatogr B Biomed Sci Appl. 1998 May 8;709(1):1-10. [2]. L S Brady, et al. Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats. J