AAF-CMK-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE AAF-CMK Cat. No.: HY-129407A CAS No.: 102129-66-8 分⼦式: C₁₆H₂₂ClN₃O₃ 分⼦量: 339.82 作⽤靶点: Ser/Thr Protease; Apoptosis 作⽤通路: Metabolic Enzyme/Protease; Apoptosis 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 AAF-CMK 是⼀种 TPPII (tripeptidylpeptidase II) 抑制剂，其具有抗肿瘤活性并可诱导细胞凋亡。AAF-CMK 可 ⽤于⽩⾎病的研究。 体外研究 AAF-CMK (0-20 μM; 24 h) shows potentiated antitumor effects of U937 leukemia cells in combination with TRAIL or TNF [1]. AAF-CMK (20 μM; 24 h) increases TNF- and TRAIL-induced U937 cell apoptosis [1]. Cell Viability Assay [1] Cell Line: U937 human promonocytic leukemia cells Concentration: 0-20 μM Incubation Time: 24 h Result: Resulted in the potentiation of growth inhibitory cytostatic effects of TRAIL as well as TNF. Apoptosis Analysis [1] Cell Line: U937 human promonocytic leukemia cells Concentration: 20 μM Incubation Time: 24 h 1/2 Master of Bioactive Molecul