Acetylastragaloside-I-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Acetylastragaloside I Cat. No.: HY-N1985 CAS No.: 84687-47-8 分⼦式: C₄₇H₇₄O₁₇ 分⼦量: 911.08 作⽤靶点: Parasite 作⽤通路: Anti-infection 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Acetylastragaloside I 是⼀种糖苷，可以从长⼩苞蔓黄芪的根中分离出。Acetylastragaloside I 是第⼀个具有显 著的锥⾍杀灭活性的环阿坦型三萜，对布⽒罗得西亚锥⾍和美洲锥⾍的 IC50 值分别为 9.5 和 5.0 μg/mL。 Acetylastragaloside I 可⽤于锥⾍感染的研究。 IC50 Target IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), ＞30 μg/mL (L. donovani), ＞20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells) [1] 体外研究 Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity to T. brucei rhodesiense, T. cruzi, L. donovani and P. falciparum with IC50 values of 9.5, 5.0, ＞30 and ＞20 μg/mL, respectively [1].Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells [1]. Cell Cytotoxicity Assay [1] Cell Line: Rat skeletal myoblasts (L6) cell line Concentration: 0.123-90 μg/mL Incubation Time: 72 hours Result: