Acyline-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Acyline Cat. No.: HY-16027 CAS No.: 170157-13-8 分⼦式: C₈₀H₁₀₂ClN₁₅O₁₄ 分⼦量: 1533.21 作⽤靶点: GnRH Receptor 作⽤通路: GPCR/G Protein 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Acyline，GnRH 多肽类似物，是⼀种 GnRH 拮抗剂，可以抑制促性腺激素和睾酮 (T) ⽔平。 体内研究 Acyline (50 μg, s.c., twice daily, 5 days) can result in disruption of vaginal oestrus and reduce uterine weights in female Kiss1−/−and Gpr54−/− mice, as well as a decrease in LH concentrations of female Kiss1−/− mice [1]. Acyline (50 μg, s.c., once) can reduce FSH concentrations from pre-acyline 1.51 ng/mL to post-acyline 1.27 ng/mL in male Kiss1−/− mice and from pre-acyline 2.87 ng/mL to post-acyline 1.95 ng/mL in male Gpr54−/− mice [1]. Animal Model: Female Kiss1−/−and Gpr54−/− mice [1] Dosage: 50 μg (1 mg/mL in PBS) Administration: Subcutaneous injection; twice daily; 5 days Result: 12 Kiss1−/− mice left oestrus within 4 days of 13 mice received acyline while only 2 of 17 mice received v