Antitrypanosomal-agent-9-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Antitrypanosomal agent 9 Cat. No.: HY-Q40175 CAS No.: 438474-67-0 分⼦式: C₂₂H₂₇NO₃ 分⼦量: 353.45 作⽤靶点: Parasite 作⽤通路: Anti-infection 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 Antitrypanosomal agent 9 (compound 1) 是⼀种有效的抗锥⾍体剂。Antitrypanosomal agent 9 显⽰出对 T. b. brucei 的抑制活性，其 IC50 为 1.15 μM。Antitrypanosomal agent 9 可⽤于⼈类⾮洲锥⾍病 (HAT) 研究。 体外研究 Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively [1]. Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM [1]. REFERENCES [1]. Manos-Turvey Alexandra, et al. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. Med Chem Commun. 2015, 6(3), 403–406. McePdfHe