Aminocandin-HMR-3270-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Aminocandin Cat. No.: HY-P0068 CAS No.: 227472-48-2 Synonyms: HMR 3270; IP960; NXL201 分⼦式: C₅₆H₇₉N₉O₁₄ 分⼦量: 1102.28 作⽤靶点: Fungal 作⽤通路: Anti-infection 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Aminocandin (HMR 3270) 是⼀种⽔溶性的棘⽩菌素类抗真菌剂 (antifungal)，对 Aspergillus 和 Candida spp. 具有良好的活性。 IC50 Target Fungal [1] 体外研究 Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L [2]. Aminocandin shows half-life of 48-58 h [2]. 体内研究 Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice [1]. Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice [2]. Animal Model: Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model [1]