Ala1-3-11-15-Endothelin-53-63-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE [Ala1,3,11,15]-Endothelin (53-63) Cat. No.: HY-P1019 CAS No.: 121204-87-3 分⼦式: C₁₀₉H₁₆₃N₂₅O₃₂S 分⼦量: 2367.67 Sequence Shortening: ASASSLMDKEAVYFAHLDIIW 作⽤靶点: Endothelin Receptor 作⽤通路: GPCR/G Protein 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 [Ala1,3,11,15]-Endothelin (53-63) 是⼀种 ETB 激动剂。[Ala1,3,11,15]-Endothelin (53-63) 对 ETB 具有选择性 ，IC50 值范围为 0.33 nM ⾄ 0.61 nM。[Ala1,3,11,15]-Endothelin (53-63) 可⽤于⾎管收缩的研究。 IC50 Target IC50 for ETB: 0.61 nM (Bronchus); 0.61 nM (Lung); 0.33 nM (Cerebellum); 2200 nM (VSMC) [1] 体外研究 [Ala1,3,11,15]-Endothelin (53-63) (0.1 μM) has selectivity for ETB with IC50 values of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM in Bronchus, Lung, Cerebellum and VSMC, respectively [1]. REFERENCES [1]. Nakamichi K, et al. Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1. Biochem Biophys Res Commun. 1992 Jan 15;182(1):144-50. McePdfHeight Caut