Glucagon-22-29-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Glucagon (22-29) Cat. No.: HY-P3617 CAS No.: 32204-93-6 分⼦式: C₄₉H₇₁N₁₁O₁₂S 分⼦量: 1038.22 Sequence Shortening: FVQWLMNT 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Glucagon (22-29) 是 Glucagon (19–29) 的部分激动剂。Glucagon 特异性抑制肝质膜 Ca2+ 泵，独⽴于腺苷 酸环化酶激活。 体外研究 Glucagon (22-29) produces only a 5-15% maximal inhibition of (Ca2+-Mg2+) ATPase, with a low potency (Ki=1 μM), similar to that of native glucagon [1]. Glucagon (22-29) (10 nM) evokes an early small decrease of cell contraction when added alone and an 18% significant positive inotropic effect when added in combination with 30 nM glucagon. Glucagon (22-29) thus appears to act as a partial agonist of miniglucagon [2]. Glucagon (22-29) consists of the COOH-terminal part of miniglucagon but lacks the three Ala1g-Gln20- Asp21 residues [2]. REFERENCES