CART治疗的学习材料.pptxVIP

CART治疗的学习材料;一、 CAR-T;一、 CAR-T;一、 CAR-T;一、 CAR-T;二、Design of ON-switch CARs;四、A. Identification of a dual input gated ON-switch CAR construct B. ON-switch CAR architecture is compatible with alternative heterodimerization modules and alternative antigen binding domains;五、Single molecule imaging shows that two components of the ON-switch CAR only assemble in the presence of small molecule dimerizer;六、A. ON-switch CAR requires small molecule AND antigen to activate primary human CD4+ T cells B.ON-switch CAR T cells require both antigen and small molecule dimerizer to drive cell prol