18F-FDGPET-CT与CT在非小细胞肺癌免疫治疗效果评价方面的对比研究.docxVIP

? ? 18F-FDGPET-CT与CT在非小细胞肺癌免疫治疗效果评价方面的对比研究 ? ? 【Summary】 目的 应用PET-CT对非小细胞肺癌免疫治疗效果进行评价，与CT评价进行对比。方法 选取60例非小细胞肺癌免疫治疗前后患者的PET-CT图像资料，进行分析，测量最大标准化摄取值（maximum standardized uptake,SUVmax），比较其免疫治疗前后的变化，评估患者免疫治疗的效果，与CT评价进行对比。结果 60例非小细胞肺癌免疫治疗后，PET-CT肺部病灶SUVmax降低30例，SUVmax无变化6例，SUVmax升高24例；CT评价病灶体积缩小24例，病灶体积无变化6例，病灶体积增大30例。其中3例病灶体积无变化，但是PET显示病灶代谢减低，3例病灶体积增大，但是PET显示病灶代谢减低。结论? PET-CT可以对肺癌免疫治疗的效果进行很好的评价，对病灶代谢情况（即SUVmax变化情况）进行评估，与CT常规评价方法相比，PET-CT对病灶变化的评价更加精准。 【Keys】肺癌;免疫治疗；效果评价 A comparative study of 18F-FDG PET-CT and CT in the evaluation of immunotherapy for non-small cell lung cancer 【 Abstract 】 Objective To evaluate the effect of immunotherapy on non-small cell lung cancer with PET-CT and compare with CT. Methods PET-CT images of 60 patients with non-small cell lung cancer before and after immunotherapy were analyzed to measure maximum standardized uptake (SUVmax) and to evaluate the effectiveness of immunotherapy. Compared with CT evaluation. Results After immunotherapy in 60 cases of NSCLC, SUVmax was decreased in 30 cases, unchanged in 6 cases, and increased in 24 cases. CT evaluation showed that the lesion volume decreased in 24 cases, remained unchanged in 6 cases, and increased in 30 cases. In 3 cases, there was no change in lesion volume, but PET showed decreased lesion metabolism, and in 3 cases, the lesion volume increased, but PET showed decreased lesion metabolism. Conclusion PET-CT can effectively evaluate the effect of immunotherapy for lung cancer, and evaluate the metabolic status of lesions (i.e.the change of SUVmax). Compared with conventional CT evaluation method, PET-CT can evaluate the changes of lesions more accurately. 【 Key words 】 Lung cancer; Immunotherapy; Effect evaluation 肺癌是最常见的肿瘤，患病率高，死亡率高。非小细胞肺癌（nonsmall cell lung cancer, NSCLC）占肺癌的 80%～85%[1]。临床上视具体病情采用手术、放疗、全身化疗、靶向治疗、热疗、中医中药等多种治疗方法，近年来，免疫治疗方法为非小细胞肺癌的治疗开辟了一条新的途径。因为免疫治疗疗程长，治疗效果不易评价，多数患者很难坚持治疗[2][3]。临床上确切需要一种好的方法来评价免疫治疗的疗效，为患者建立治疗信心，也为临床医师制定科学的治疗方案提供依据。?? 临床通常使用CT技术来评价非小细胞肺癌免疫治疗的效果。CT主要依据肺