obligateanaerobes近畿大学医学部.pptxVIP

obligateanaerobes近畿大学医学部第1页/共66页第2页/共66页March to July 2009, Emerging infectious disease identified as the severe fever with thrombocytopenia syndrome (SFTS) in rural central China. Cause was unknown.Major clinical symptoms included fever, thrombocytopenia, gastrointestinal symptoms, and leukocytopenia; high initial case fatality rate of 30%Multi-organ failure developed RAPIDLY—elevated serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, lactate dehyrogenase; proteinuria, hematuria.From Dr. O’Callaghan Virology Journal Club April 29, 2011第3页/共66页Family Bunyaviridae5 generaGenus Human diseaseOrthobunyavirus La Crosse encephalitis, California encephalitis Phlebovirus Rift Valley fever (RVF)Nairovirus Crimean-Congo hemorrhagic fever (CCHF)Hantavirus Hemorrhagic fever with renal syndrome (HFRS) Hantavirus pulmonary syndrome (HPS)Tospovirus Plant virus, no known human diseaseEncephalitisHemorrhagic FeverPneumonia第4页/共66页BUNYAVIRIDAE; Bunyamwera in UgandaVirion: ENV, 120nm; 3 Helical capsids; three 1X RNAs5 Genera. 2 genera have ambisense RNAs; Phelbovirus TospovirusCaliforniaSin NombreCCHFRift ValleyS+M RNAs = ambiTospovirus genus = tomato spotted wilt virusM S RNAs are ambisense. NSm 34K protein = movement. Forms tubules that penetrate thru plasmadesmata so capsids can enter neighboring cell. NSs 52K protein binds 2X RNA that can generate siRNAs . Transmitted by THIRPSInfects tomato, peanuts, watermelon, zucchini, impatiensDr. O’Callaghan Journal Club 4/20/12第5页/共66页Hantavirus (HFRS contact with rodents) Nairovirus (CCHF-tick)Orthobunyavirus (LAC mosquito)Phlebovirus (Rift Valley Fever; mosquito)Tospovirus (Tomato spotted wilt ; thrips)PHLEBOVIRUS: 68 serotypes. Two Groups: 1. Phlebotomus Fever Group 55 (sandflies) 2. Uukuniemi Group 13 (ticks) Eight members linked to disease humans Alenquer Chaniru Chagres Naples Punta To