hPPARs天然配体筛选平台的建立及应用的开题报告.docxVIP

hPPARs天然配体筛选平台的建立及应用的开题报告 摘要 PPARs是一类与动物生理及疾病密切相关的核受体分子，具有广泛的生物学功能和医学价值。目前已知有三种PPARs亚型，分别为PPARα、PPARβ/δ、PPARγ，它们分别参与着脂代谢、糖代谢、免疫调节、细胞分化等生物过程，因此成为激发众多生物学家和药学家关注的研究热点。与此同时，PPARs也成为了临床治疗相关疾病的重要靶点。但是，PPARs的药物研发仍然存在挑战，其中的一个难点在于合适的PPARs天然配体对药物研发的重要性，但目前已知的PPARs天然配体仍然相对有限。因此，本文根据目前已知的PPARs天然配体的结构特征，建立一个已知化合物筛选数据库，从中寻找潜在的治疗PPARs相关疾病的天然化合物，从而建立了一个PPARs天然配体筛选平台，并进行了初步的实验验证。 关键词：PPARs，天然配体，药物研发，筛选平台，实验验证 Abstract PPARs are a class of nuclear receptor molecules that are closely related to animal physiology and diseases, and have wide biological functions and medical value. Three PPAR subtype are currently known, including PPARα, PPARβ/δ, and PPARγ, which are involved in lipid metabolism, glucose metabolism, immune regulation, cell differentiation and other biological processes, and have become a research hotspot of many biologists and pharmacists. At the same time, PPARs have also become an important target for the clinical treatment of related diseases. However, the drug development of PPARs still faces challenges, and one of the difficulties is the importance of suitable PPARs natural ligands for drug development, but the currently known PPARs natural ligands are still relatively limited. Therefore, based on the structural characteristics of the currently known PPARs natural ligands, this paper establishes a known compound screening database, and finds potential natural compounds for the treatment of PPARs related diseases from it, thus establishing a PPARs natural ligand screening platform and conducting preliminary experimental verification. Keywords: PPARs, natural ligands, drug development, screening platform, experimental verification