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Antihistamines: 25 H - and H -Blockers 1 2 Recognition PROBLEM YSIS An overview of the side effects associated with antihista- Definition mines is provided in Table 25-1. A more detailed description of the physiology behind these effects follows. Antihistamines (H -blockers) are a family of drugs used for 1 hypersensitivity reactions of various types. Antihistamines H -BLOCKERS are easily obtained, even without a prescription, but are 1 not of adverse side effects. Also, most first-generation H -receptor antagonists competitively inhibit the in c- 1 H -antagonists, such as diphenhydramine, inhibit mus- tion of histamine with the H -receptor, thereby inhibiting 1 1 carinic receptors to cause anticholinergic effects; the elderly the vasodilator effects of histamine and preventing the are especially prone to these side effects of H -blockers. occurrence of edema, flare, and wheal. H -antagonists are 1 1 Common side effects of first-generation antihistamines are taken primarily f