药理学英文版教学课件：Chapter 10 Cholinoceptor Antagonist.pptVIP

Cholinoceptor Antagonist (p50) Case 1Male, 30 yrs old, farmerbegan progressively abdominal pain 5 hours ago, accompanied by tachypnea（呼吸急促） and tremor, then fill into coma. PE found: profuse sweating（大汗）, salivation, teeth clenched, sursumversion(两眼上翻)，vomitting, tromer, urinary and fecal incontinence（失禁）, dysphoric(烦躁不安). HR increased and miosis (瞳孔缩小)in eye.History: clothes drenched（浸透） with organophosphate solution when worked in the farmland this morning.Treatment: skin washing with clear water; i.v atropine; i.v PAM(解磷定) Cholinoceptor antagonists have affinity but no intrinsic