巴戟天糖链对血管新生中Notch信号通路的作用研究的中期报告.docxVIP

巴戟天糖链对血管新生中Notch信号通路的作用研究的中期报告 【摘要】巴戟天为常用中药，具有多种药理活性。其中，巴戟天多糖和巴戟天皂苷是其主要有效成分。本研究旨在探讨巴戟天糖链对血管新生中Notch信号通路的影响。研究采用小鼠卵巢细胞株（MOECs）构建风干法人工模型，模拟血管新生。研究发现，巴戟天糖链可以促进MOECs血管新生，增加Notch1、Notch2和Dll4的表达，同时抑制Notch3和Jag1的表达。这表明巴戟天糖链通过调节Notch信号通路促进血管新生，为其应用于心血管疾病治疗提供了理论基础。 【关键词】巴戟天糖链；Notch信号通路；血管新生；MOECs 【Abstract】Gynostemma pentaphyllum is a commonly used Chinese medicine with multiple pharmacological activities. Gypenosides and polysaccharides are the main active ingredients of Gynostemma pentaphyllum. The aim of this study was to investigate the effect of Gynostemma pentaphyllum polysaccharides on the Notch signaling pathway in angiogenesis. The study used mouse ovarian cell lines (MOECs) to construct an artificial model by air-drying method to simulate angiogenesis. The study found that Gynostemma pentaphyllum polysaccharides can promote MOECs angiogenesis, increase the expression of Notch1, Notch2, and Dll4, while inhibiting the expression of Notch3 and Jag1. This indicates that Gynostemma pentaphyllum polysaccharides promote angiogenesis by regulating the Notch signaling pathway, providing a theoretical basis for its application in the treatment of cardiovascular diseases. 【Keywords】Gynostemma pentaphyllum polysaccharides; Notch signaling pathway; angiogenesis; MOECs