解氏肺癌三号方对小鼠Lewis肺癌作用的研究的中期报告.docxVIP

解氏肺癌三号方对小鼠Lewis肺癌作用的研究的中期报告 Abstract In this study, we aimed to investigate the anti-cancer effects of JieShi Lung Cancer Formula No. 3 (JSF3) on Lewis lung carcinoma (LLC) in mice. JSF3 is a traditional Chinese herbal medication that has been used to treat lung cancer patients in China. Thirty mice with LLC were randomly divided into three groups: control, low-dose JSF3, and high-dose JSF3. The control group was administered saline, and the treatment groups were administered JSF3 at doses of 2.5 or 5 g/kg body weight once a day for 20 consecutive days. At day 20, mice were sacrificed and the tumor tissues were collected and analyzed. The results showed that JSF3 significantly inhibited LLC growth in a dose-dependent manner compared to the control group. The high-dose JSF3 group had the most significant difference in tumor size and weight compared to the control group (p 0.05). Moreover, JSF3 also suppressed tumor cell proliferation and induced tumor cell apoptosis in a dose-dependent manner. In conclusion, our findings suggest that JSF3 has potent anti-cancer effects on Lewis lung carcinoma in mice. Further studies are needed to identify the active components in JSF3 and elucidate the underlying mechanisms of its anti-cancer effects. Keywords: JieShi Lung Cancer Formula No. 3, Lewis lung carcinoma, anti-cancer, apoptosis, traditional Chinese herbal medication.