病理学—呼吸系统疾病.ppt

* The TH2 cytokines IL-4, IL-5, and IL-13 are important mediators. Triggers for non-atopic asthma are less clear but include viral infections and inhaled air pollutants. Eosinophils are key inflammatory cells found in all subtypes of asthma; bronchial asthma * eosinophil products such as major basic protein are responsible for airway damage. Airway remodeling (basement membrane thickening and hypertrophy of bronchial smooth muscle) adds to the element of obstructive disease. bronchial asthma * Bronchiectasis is the permanent dilation of bronchi and bronchioles caused by destruction of the