脑血管痉挛防治策略演示文稿.pptVIP

1996年Barker FG 等人就关于尼莫地平预防蛛网膜下腔出血后的脑血管痉挛的试验进行荟萃分析，共纳入7项随机对照试验，结果表明预防性应用尼莫地平可以显著改善SAH患者的预后，包括总体的病死率和病残率以及总体的预后，P值分别为0.004和0.0007，NNT（需要治疗的数量）分别为7和10。 Good outcome versus all other grades: 1.86 (99% CI: 1.07, 3. 25, p=0.004; p(Q)=0.11). Good or fair outcome versus all other grades: 1.67 (99% CI: 1. 13, 2.46, p=0.0007; p(Q)=0.43). Overall mortality: 0.73 (99% CI: 0.42, 1. 25, p=0.1; p(Q)=0.22). Deficit or mortality attributed to vasospasm or DID: 0.46 (99% CI: 0.31, 0.68, p0.00001; p(Q)=0.64). Mortality attributed to vasospasm or DID: 0.50 (99% CI: 0.26, 0.97, p=0.007; p(Q)=0.55). 预防性应用尼莫地平显著减少由