甲磺酸伊马替尼的耐药机制及逆转策略.docxVIP

甲磺酸伊马替尼的耐药机制及逆转策略 吴荣娟 【摘要】Drug resistance in leukemia is a major obstacle to successful chemotherapies.Imatinib mesy-late has been demonstrated to be effective in the treatment of chronic myelogenous leukemia, but the drug resistance phenomena has increased along with the wide application of imatinib, which has greatly limited the clinical usage. Currently,resistance to imatinib is believed to be a consequence of the interaction of multiple factors. Methods for reversal of drug resistance are in-depth study. Here is to make a review on the mecha-nisms of resistance and some strategies for ove