生物标记物在重症感染的临床价值.pptx

重症感染患者生物标记物 的临床价值;什么是生物标记物(Biomarkers);理想的生物标记物;Biomarkers for pneumonia;5;Biomarkers related to sepsis;Biomarkers related to sepsis;8;Lancet Infect Dis 2013;13: 4926–35;? Use of low procalcitonin levels or similar biomarkers to assist the clinician in the discontinuation of empiric antibiotics in patients who initially appeared septic, but have no subsequent evidence of infection (grade 2C). ? No recommendation can be given for the use of these markers to distinguish between severe infection and other acute inflammatory states Crit Care Med 2013; 41:580–637 10;11;Journal of Infection(2010) 60, 4091-4216;Diagnosing non-infectious fever;Diagnosing non-infectious fever;15;16;Expert Rev. Respir. Med. 6(2), 203–214 (20121) 7;Family Practice 2012; 29:383–393 18;Biomarkers for pneumonia;Biomarkers for pneumonia;;Discriminating Pathogens;Discriminating Pathogens;Discriminating Pathogens;Discriminating Pathogens;Discriminating Pathogens;27;Predicting Severity;Predicting Severity;Predicting Severity;Predicting Severity;Predicting prognosis;Predicting Prognosis;Predicting Prognosis;2015-8-182015-8-18;Curr Opin Crit Care 2013, 19:453–46036;Guiding Antibiotic Therapy;Guiding Antibiotic Therapy;An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients ? Procalcitonin guided antibiotic therapy algorithms could help in reducing the duration of antimicrobial administration without having a negative impact on survival;? Use of low procalcitonin levels or similar biomarkers to assist the clinician in the discontinuation of empiric antibiotics in patients who initially appeared septic, but have no subsequent evidence of infection (grade 2C). ? No recommendation can be given for the use of these markers to distinguish between severe infection and other acute inflammatory states Crit Care Med 2013; 41:580–637 40;PSI：肺炎严重程度指数（Pneumonia severity index） Curr Opin Infect Dis 2013, 26:159–16471;42;Curr Opi