发育生物学与再生医学学习资料:Biology of Aging.docVIP

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发育生物学与再生医学学习资料:Biology of Aging.doc

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BiologyofAging

Agingisaprocessofgeneral,irreversible,andprogressivephysicaldeteriorationthatoccursovertime.

Cellsenescence:whenthecellstopdividing,theyappeartobehealthy,butarestuckatsomepointinthecellcycle,oftenG0;thisphenomenonisknownasCellsenescence.

Thecharactersofcellularsenescence

Energygenerationpotentialofthemitochondriadeclines

DNAdamageaccumulates

Levelsofdamagedproteinincreases

Newproteinsynthesisdeclines

Cellsaccumulateinsolubledeposits

Themechanismsofsenescenceinvolved:boththeabilitytoresistdamag

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