GSK-J1-sodium-DataSheet-生命科学试剂-MCE.pdf

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GSK-J1sodium

Cat.No.:HY-15648G

CASNo.:1797832-71-3

分⼦式:C₂₂H₂₂N₅NaO₂

分⼦量:411.43

作⽤靶点:HistoneDemethylase

作⽤通路:Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性GSK-J1sodium是H3K27me3/me2-demethylasesJMJD3/KDM6B和UTX/KDM6A的抑制剂，对KDM6B的

IC50值为60nM。

IC50TargetIC50:60nM(KDM6B)[2]

客户使⽤本产品发表的科研⽂献

•ActaPharmacolSin.2021Apr13.

•Oncogene.2021Apr;40(15):2711-2724.

•FrontMolNeurosci.2017Mar13;10:51.

•JChromatogrA.2020Feb22;1613:460625.

•MolDivers.2024Mar24.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].KruidenierL,etal.AselectivejumonjiH3K27demethylaseinhibitormodulatestheproinflammatorymacrophageresponse.Nature.2012

Aug16;488(7411):404-8.

[2].HeinemannB,etal.InhibitionofdemethylasesbyGSK-J1/J4.Nature.2014Oct2;514(7520):E1-2.

[3].HortonJR,etal.CharacterizationofaLinkedJumonjiDomainoftheKDM5/JARID1FamilyofHistoneH3Lysine4Demethylases.JBiol

Chem.2016Feb5;291(6):2631-46.

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